Eagles and Jaguars Kick Off in London, Then the Undefeated 49ers Walk Into Seattle: Every NFL Sunday Game That Matters

LONDON

The breakfast game is the headliner. Philadelphia and Jacksonville open NFL Sunday at Tottenham Hotspur Stadium (9:30 a.m. ET, NFL Network), and the team everyone is worried about is the one that isn't healthy: the Eagles.

Philadelphia declared five starters out in London: running back Saquon Barkley (hamstring), receiver DeVonta Smith (hamstring — his second straight missed game), receiver Marquise “Hollywood” Brown (ankle), center Drew Kendall (knee) and safety Marcus Epps (groin). Edge rusher Jonathan Greenard didn't practice all week with an ankle injury and was ruled out after a pregame field test, per the Delaware News Journal's live coverage from London. Backup running back Tank Bigsby is on injured reserve, so the ground game falls to Will Shipley and newly promoted Dameon Pierce, with Carson Steele elevated from the practice squad. Quarterback Jalen Hurts was a full participant in practice despite a calf listing and is cleared to play.

The Eagles (2-2) have lost two straight and are a shell of themselves on offense. The offensive line is being rebuilt on the fly: Lane Johnson's abrupt retirement was announced October 6 (the Eagles haven't made it official for salary-cap reasons, which leaves the door cracked for a return), Cam Jurgens was traded, and the line that takes the field in London will feature unfamiliar faces — Jake Majors at center and Willie Lampkin at left guard in pregame drills. For a team that built its identity in the trenches, that's a problem — and Jacksonville (3-1) knows it.

The Jaguars have won two straight, including a 22-17 win over Cincinnati last week, and they're catching Philadelphia at exactly the right time. Trevor Lawrence has emerging help in running back Bhayshul Tuten and tight end Brenton Strange, and two-way star Travis Hunter is coming off one of his best games as a pro. But their own defense is held together with tape: only five healthy defensive backs finished the Bengals game. Starting safety Eric Murray (concussion) is out and backup Caleb Ransaw went to injured reserve, which could force third-round rookie Jalen Huskey into real snaps in his NFL debut. Cornerback Jaylon Jones (hamstring) is also out.

History says beware the chalk. Philadelphia leads the series 5-3, won the last meeting 28-23 in 2024, and the Jaguars haven't beaten the Eagles since October 29, 2006. But London has been Jacksonville's second home since 2013 — 14 games there, 7-7 overall — and this is the team's third London double (they went 3-1 in the two previous ones). Next week: the Texans, October 18, also in London. Liam Coen's Jaguars went 13-4 last season and made the postseason for the first time since 2022, and the whole Florida Times-Union staff is picking Jacksonville on Sunday.

The money has heard all of this. Jacksonville is a 7.5-point favorite (-375 on the moneyline, Philadelphia +300) with a 41.5-point total, per the BetMGM line cited in the Florida Times-Union's game preview. NFL Network's broadcast team: Dave Pasch, Kurt Warner, Travis Kelce and Molly McGrath.

The 1 p.m. ET slate

Eight games at 1 p.m. ET. The TV split: FOX carries Bengals-Dolphins, Vikings-Saints, Giants-Commanders and Bears-Packers; CBS has Raiders-Patriots, Browns-Jets, Colts-Steelers and Texans-Titans.

The Las Vegas angle is the early window's most-watched game in this market: Raiders at Patriots. Our full Raiders-Patriots preview is here — and the Raiders' week has been defined by the injury report, with rookie running back Ashton Jeanty questionable and two rookies elevated to the roster, as our newsroom covered in full. New England is the kind of place where a banged-up team goes to get exposed.

Elsewhere at 1 p.m.: the Bengals visit Miami with Cincinnati trying to keep its season from unraveling; Minnesota heads to New Orleans; Cleveland and the Jets play a game that will determine draft position more than playoff seeding; Indianapolis visits Pittsburgh in an AFC grinder; Houston is at Tennessee; the Giants visit Washington; and Chicago heads to Green Bay in a rivalry that never needs selling.

The late window — NFC West supremacy on the line

This is the game of the week. San Francisco (4-0) at Seattle (3-1), 4:25 p.m. ET on FOX, at Lumen Field.

The 49ers are one of three remaining undefeated teams, and they're doing it with balance: Brock Purdy has 1,007 yards with 11 touchdowns and one interception, San Francisco has scored 30.5 points a game, and the Niners just handled Denver 24-14. They're also doing it without Nick Bosa (out), and the injury list is long enough that our newsroom has been tracking the 49ers' injuries daily.

Standing in the way: the defending Super Bowl champions. Seattle is 3-1, coming off a 30-23 win over the Chargers, and the Seahawks have owned this matchup lately — including a 41-6 demolition in last January's playoffs and a 13-3 win at Levi's in the season finale. The 49ers are 6-4 against the spread in the last 10 meetings, but recent history at Lumen Field has been ugly for San Francisco.

Seattle is a 3-point home favorite (-155 moneyline, 49ers +130) with the total at 47.5, per DraftKings via Sports Illustrated. Division games, road underdog, unbeaten team getting points — the betting world will have opinions. The Ticket desk's position: nobody should be surprised if this is the game where 4-0 dies.

The other late games: Denver at the Chargers (4:05 p.m. ET, CBS) and Detroit at Arizona (4:25 p.m. ET, FOX).

Sunday night, then Monday

Baltimore at Atlanta caps the day at 8:20 p.m. ET on NBC and Peacock — the Ravens on the road against a Falcons team that needs every win it can get in a crowded NFC. And don't forget Monday night: Buffalo at the Rams, 8:15 p.m. ET, on ESPN Unlimited.

More from the newsroom: our full Raiders-Patriots preview · the 49ers' injury crisis · Monday's ALCS Game 1 preview